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Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increased plasma renin activity and angiotensin II circulating levels do not overcome the effect of valsartan on blood pressure

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The class as a whole represents a notable expansion of the proteome attributable to mitochondrial DNA, which had previously been understood to encode only a small set of structural and respiratory chain proteins